Ardisia japonica is a well-known traditional Chinese medicinal herb used as a diuretic, for treating cough and for stopping uterine\nbleeding. A simple, sensitive, and reliable LC-MS/MS method was developed to determine six active compounds in rat plasma and\nthis method was further applied to the pharmacokinetic study of these compounds after oral administration of Ardisia japonica\nextract. Acetonitrile was used to precipitate the protein in the plasma samples. Using acetonitrile and formic acid aqueous solution\n(0.05%) as themobile phase, the separation of the six compounds and internal standards was achieved at a flow rate of 300
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